منابع مشابه
Sputum myeloperoxidase in chronic obstructive pulmonary disease
BACKGROUND Airway inflammation, especially neutrophilic airway inflammation, is a cardinal pathophysiologic feature in chronic obstructive pulmonary disease (COPD) patients. The ideal biomarkers characterizing the inflammation might have important potential clinical applications in disease assessment and therapeutic intervention. Sputum myeloperoxidase (MPO) is recognized as a marker of neutrop...
متن کاملCyanate-mediated inhibition of neutrophil myeloperoxidase activity.
Cyanate (CNO-) forms spontaneously in solutions containing urea, and is present in urine and the body fluids of uraemic patients. We have explored the possibility that CNO- might be one of the unknown substances responsible for the reported impairment, by urine and uraemic plasma, of neutrophil oxidative metabolism (especially as measured by luminol-enhanced chemiluminescence). Luminol-enhanced...
متن کاملStudies on the chlorinating activity of myeloperoxidase.
Two methods were utilized to demonstrate the peroxidation of chloride ion to a free species (HOCl or Cl2) by myeloperoxidase. The peroxidase caused the volatilization of radioactivity from soultions containing hydrogen peroxide and [36Cl]NaCl, and catalyzed the formation of HOCl when solutions contianing these components were passed through a Millipore filter to which the peroxidase was adsorbe...
متن کاملMyeloperoxidase exerts microbicidal activity against Mycobacterium tuberculosis.
We investigated the antimycobacterial role of myeloperoxidase (MPO), one of the most abundant granule proteins in human neutrophils. Our data indicate that purified MPO, in the presence of hydrogen peroxide, exerts a consistent killing activity against Mycobacterium tuberculosis H37Rv and against a clinical isolate. The activity is time and dose dependent and requires the presence of chloride i...
متن کاملHigh neutrophil myeloperoxidase activity in smokers.
He also observed that the increase in MPO preceded the development of macrocytosis in megaloblastic anemia, thus suggesting that the threshold for the development of macrocytosis is higher than that for the development of increased MPO activity. We studied neutrophil MPO activity using the method of Herzog and Fahimi' and neutrophil MPO scoring by the method of Kaplow'in 40 chronic smokers (blo...
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ژورنال
عنوان ژورنال: BIO-PROTOCOL
سال: 2013
ISSN: 2331-8325
DOI: 10.21769/bioprotoc.851